Thesis Supervisor 1 Retno Aulia Vinarti, S.Kom., M.Kom., Ph.D.
Thesis Supervisor 2 Renny Pradina, S.T., M.T.
App and Design by Muhammad Rasyad Caesarardhi
Data processed and summarized using Bringing Order to Abstractive Summarization paper
Original data provided by Atlas of Human Infectious Diseases
| Subjects | Quick Description (AI) |
|---|---|
DiseaseDisease - Original textRift Valley Fever | Rift Valley Fever |
ClassificationClassification - Original textICD-9 066.3; ICD-10 A92.4 | ICD-9 066.3; ICD-10 A92.5 |
Syndromes and synonymsSyndromes and synonyms - Original textNone. | none. |
AgentAgent - Original textRift Valley fever virus (RVFV), an enveloped, singlestranded tripartite RNA virus, belonging to the genus Phlebovirus of the family Bunyaviridae. There are three lineages: Egyptian, West African, and East-Central African. Zinga virus, isolated in 1982 inMadagascar, was later found to be a strain of RVFV. | rift valley fever virus (rvfv) |
ReservoirReservoir - Original textLivestock (cattle, camels, goats, sheep), wild buffalo, waterbuck, some rodents. | livestock (cattle, camels, goats, sheep), wild buffalo, waterbuck, some rodents. |
VectorVector - Original textMosquitoes of the genera Aedes, Culex, Mansonia and others. There is transovarian transmission of RVFV in mosquitoes. Dried mosquito eggs can remain viable and infected for years. Originally, the eggs are laid in the damp soil above the water line and hatch when flooded. | mosquitoes of the genera aedes, culex, mansonia and others. |
TransmissionTransmission - Original textHuman infections occur via two main transmission routes: (1) mosquito bite, and (2) direct or indirect contact with the blood or organs of infected animals (e.g. slaughtering, butchering, veterinary procedures, animal births, disposing of carcasses or fetuses) by percutaneous inoculation or inhaling aerosols. Transmissionmay be possible via consumption of raw milk of an infected animal. Person-toperson transmission has not been described. However, humans develop high viral loads in the blood, and may transmit virus to contacts. | human infections occur via two main transmission routes: (1) mosquito bite, and (2) direct or indirect contact with the blood or organs of infected animals (e.g. slaughtering, butchering, veterinary procedures, animal births, disposing of carcasses or fetuses) |
CycleCycle - Original textAnimal–mosquito–animal with spillover to humans in epidemics via direct/indirect contact to infected animal tissue or mosquito bite. | animal–mosquito–animal with spillover to humans in epidemics via direct/indirect contact to infected animal tissue or mosquito bite. |
Incubation periodIncubation period - Original text2–6 days. | 2–6 days. |
Clinical findingsClinical findings - Original textA self-limiting disease that lasts for about 4 to 7 days. Patients usually experience dengue-like illness with fever, muscle pain, headache, and joint pain. The disease may progress in some cases to one or more of three distinct syndromes: ocular (eye) disease (0.5–2% of patients) with retinitis and possible blindness; meningoencephalitis (about 1%), patients usually recover; or acute hepatitis and hemorrhagic fever (about 1%) with a CFR of 50%. Some patients are misdiagnosed as meningitis. | a self-limiting disease that lasts for about 4 to 7 days. patients usually experience dengue-like illness with fever, muscle pain, headache, and joint pain. |
Diagnostic testsDiagnostic tests - Original textSerology (IgM ELISA or EIA); RT-PCR on blood in early phase of disease; virus isolation in specialized laboratories. | serology (igm elisa or eia); rt-pcr on blood in early phase of disease; virus isolation in specialized laboratories. |
TherapyTherapy - Original textSupportive, there is no specific treatment. | supportive |
PreventionPrevention - Original textAn inactivated virus vaccine (not licenced) is limited available to protect laboratory workers, veterinarians and others ‘at risk.’ Livestock vaccines are available, but are not licenced in Europe or the USA. Animal movement should be banned during outbreaks. Protective clothing worn by those exposed to infected animals/tissue. All animal products (blood, meat and milk) should be thoroughly cooked before eating. Infection control for those taking care of severe human cases. Personal anti-mosquito precautions. Larviciding at mosquito-breeding sites. Early warning systems for RVF are in place that use satellite images and weather/climate forecasting data. | an inactivated virus vaccine (not licenced) is limited available to protect laboratory workers, veterinarians and others ‘at risk.’ animal movement should be banned during outbreaks. protective clothing worn by those exposed to infected animals/tissue. all animal products (blood, meat and milk) should be thoroughly cooked before eating. infection control for those taking care of severe human cases. personal anti-mosquito precautions. larviciding at mosquito-breeding sites. |
EpidemiologyEpidemiology - Original textRVFV primarily causes disease in animals in Africa and Middle East, with human cases occurring during animal epidemics. Humans that regularly work with animals (farmers, herders, veterinarians, slaughterhouse workers) are at increased risk of infection. Epidemics in animals occur when mosquito populations dramatically increase after periods of heavy rainfall or the production of wetlands behind man-made dams. RVF was initially confined to Sub-Saharan Africa, but appeared in Egypt in 1977 and was discovered on the Arabian Peninsula (Saudi Arabia and Yemen) in 2000 and later also on the Comoros Islands. As RVFV epidemics are closely associated with above-average rainfall, outbreaks can be forecasted upon which preventive measures can be implemented. | rvfv primarily causes disease in animals in africa and middle east, with human cases occurring during animal epidemics. |
CommunicabilityCommunicability - Original textNaN | - |
Prepatent periodPrepatent period - Original textNaN | - |