Thesis Supervisor 1 Retno Aulia Vinarti, S.Kom., M.Kom., Ph.D.
Thesis Supervisor 2 Renny Pradina, S.T., M.T.
App and Design by Muhammad Rasyad Caesarardhi
Data processed and summarized using Bringing Order to Abstractive Summarization paper
Original data provided by Atlas of Human Infectious Diseases
| Subjects | Quick Description (AI) |
|---|---|
DiseaseDisease - Original textOropouche Virus Disease | Oropouche Virus Disease |
ClassificationClassification - Original textICD-9 065; ICD-10 A93.0 | ICD-9 065; ICD-10 A93.0 |
Syndromes and synonymsSyndromes and synonyms - Original textOropouche fever, fevre de Mojui. | oropouche fever, fevre de mojui. |
AgentAgent - Original textOropouche virus (OROV), a spherical enveloped, single-stranded, negative-sense RNA virus, belonging to the Orthobunyavirus group of the Bunyaviridae family, with 3 genotypes. | oropouche virus (orov), a spherical enveloped, single-stranded, negative-sense rna virus |
ReservoirReservoir - Original textMonkeys, three-toed sloths (Bradypus tridactylus), marsupials, and forest birds. | monkeys, three-toed sloths (bradypus tridactylus), marsupials, and forest birds. |
VectorVector - Original textDuring urban epidemics, biting midges (Culicoides paraensis); also mosquitoes of Aedes and Culex genera. | during urban epidemics, biting midges (culicoides paraensis) |
TransmissionTransmission - Original textBy insect bite. | by insect bite. |
CycleCycle - Original textThe vector becomes infected with OROV by feeding on a viremic host. The virus crosses the gut wall and multiplies in the organs of the insect. After a few days, depending on the ambient temperature, the virus reaches the salivary glands and is injected into the next host during feeding. Jungle cycle: OROV is transmitted among sloths, marsupials, primates, and birds by the mosquitoes Aedes serratus and Culex quinquefasciatus. Urban cycle: OROV is transmitted to humans by midges (Culicoides paraensis). | the vector becomes infected with orov by feeding on a viremic host. urban cycle: orov is transmitted to humans by midges (culicoides paraensis). |
Incubation periodIncubation period - Original text2–14 days. | 2–14 days. |
Clinical findingsClinical findings - Original textSudden onset fever (may be diphasic), headache, myalgia, arthralgia, anorexia, dizziness, chills, and photophobia. Also nausea, vomiting, diarrhea, epigastric and eye pain, conjunctivitis, and meningitis have been reported. Recently, spontaneous hemorrhagic phenomena were reported in human cases. The disease is self-limiting, there are no reports of OROV related deaths. | sudden onset fever (may be diphasic), headache, myalgia, arthralgia, anorexia, dizziness, chills, and photophobia. also nausea, vomiting, diarrhea, epigastric and eye pain, conjunctivitis, and meningitis |
Diagnostic testsDiagnostic tests - Original textSerology (IgM ELISA, IFA) or by detection of OROV RNA in blood by RT-PCR. | serology (igm elisa, ifa) or by detection of orov rna in blood by rt-pcr. |
TherapyTherapy - Original textSupportive, there is no specific treatment. | supportive |
PreventionPrevention - Original textPersonal anti-insect measures; there is no vaccine. Removal of culicoides breeding sites in cacao husks and felled banana trunks. | personal anti-insect measures |
EpidemiologyEpidemiology - Original textOROV was first isolated in Trinidiad in 1955. In South America, cases are limited to Trinidad, Panama, and the Amazon basin. Oropouche fever is, after dengue fever, the most common arboviral infection in Brazil. The virus has periodically caused large urban epidemics in Brazil and Peru, during which up to 60% of the population has been affected. There also outbreaks in villages and sporadic cases. Approximately 500,000 cases have occurred in Brazil since the 1960s. There are three OROV genotypes circulating in Brazil: genotypes I and II in the Amazon Basin and genotype III in the Southeast Region. Genotype III has been isolated from a marmoset (Callithrix species) in southeastern Brazil, and also occurs in Panama. Outbreaks coincide with periods of highest rainfall, when biting midge density is greatest. OROV infections are likely underdiagnosed in South America as was seen during a concurrent outbreak of dengue virus and OROV in Manus (Brazil), where OROV infections were missed by physicians and the Public Health Authority. | orov was first isolated in trinidiad in 1955. in south america, cases are limited to trinidad, panama, and the amazon basin. approximately 500,000 cases have occurred in brazil since the 1960s. |
CommunicabilityCommunicability - Original textNaN | - |
Prepatent periodPrepatent period - Original textNaN | - |