Thesis Supervisor 1 Retno Aulia Vinarti, S.Kom., M.Kom., Ph.D.
Thesis Supervisor 2 Renny Pradina, S.T., M.T.
App and Design by Muhammad Rasyad Caesarardhi
Data processed and summarized using Bringing Order to Abstractive Summarization paper
Original data provided by Atlas of Human Infectious Diseases
| Subjects | Quick Description (AI) |
|---|---|
DiseaseDisease - Original textHepatitis E | Hepatitis E |
ClassificationClassification - Original textICD-9 070.5; ICD-10 B17.2. | ICD-9 070.5; ICD-10 B17.2. |
Syndromes and synonymsSyndromes and synonyms - Original textEpidemic non-A non-B hepatitis, fecal–oral non-A non-B hepatitis, enterically transmitted nonA non-B hepatitis. | epidemic non-a non-b hepatitis, fecal–oral non- a non- b hepatitis, enterically transmitted nona nonb hepatitis. |
AgentAgent - Original textHepatitis E virus (HEV), a non-enveloped singlestranded RNA virus, genus Hepevirus, the single member in the Hepeviridae family. The virus can be classified into four genotypes (genotype HEV-1 to HEV-4), and > 24 subgenotypes (1a–1e, 2a–2b, 3a–3j, and 4a–4g). Avian isolates of HEV are now considered to be a separate genus. HEV was discovered in the 1980s as a result of a large water-borne non-A non-B hepatitis outbreak in India between 1978 and 1979. | hepatitis e virus (hev), a non-enveloped singlestranded rna virus, genus hepevirus, the single member in the hepeviridae family. |
ReservoirReservoir - Original textHumans are the natural host. Numerous mammals have serologic evidence of HEV disease, including but not limited to: pigs, cattle, sheep, goats, horses, macaques, cats, dogs, rabbits, mongoose, deer, wild boar, rats, and mice. HEV in pigs is asymptomatic, but there is transient viremia and excretion of virus into the environment. | humans are the natural host |
VectorVector - Original textNaN | - |
TransmissionTransmission - Original textFecal–oral route, mainly via fecally contaminated water, but also via: food, materno-fetal, and transfusion of blood products. Direct person-to-person transmission is uncommon. Cycle: Human to human and occasionally animal to human. HEV is excreted from the liver into the stool via the bile and eventually into the environment. The amount of infectious virus in the stool is relatively low and explains a lower rate of transmission as compared to hepatitis A (see Hepatitis A map). | fecal–oral route, mainly via fecally contaminated water, but also via: food, materno-fetal, and transfusion of blood products. cycle: human to human and occasionally animal to human. |
CycleCycle - Original textNaN | - |
Incubation periodIncubation period - Original textOn average 40 days (range: 2 to 10 weeks). | On average 40 days (range: 2 to 10 weeks). |
Clinical findingsClinical findings - Original textThe disease is self-limiting and acute symptoms are similar to acute hepatitis A disease. Children are generally asymptomatic or have mild disease. Clinical evident disease is more common in age group 15–44 years, with following symptoms: fatigue, fever, nausea, vomiting, abdominal pain, jaundice, dark urine, and light stool. Pregnant women are at risk for severe disease, including fulminant hepatitis and death. In immunocompromised persons (e.g. transplant recipients or users of immune-modulating therapy) chronic infection has been reported. | clinical evident disease is more common in age group 15–44 years, with following symptoms: fatigue, fever, nausea, vomiting, abdominal pain, jaundice, dark urine, and light stool. |
Diagnostic testsDiagnostic tests - Original textSerology (HEV IgM, IgG); HEV RNA detection in blood and stool by RT-PCR. | serology (hev igm, igg); hev rna detection in blood and stool by rt-pcr. |
TherapyTherapy - Original textSupportive. | supportive. |
PreventionPrevention - Original textHygiene; access to clean water; sanitation (see Water and Sanitation map). A vaccine has been developed and proven effective, but is not yet available. | hygiene; access to clean water; sanitation (see water and sanitation map). |
EpidemiologyEpidemiology - Original textHEV is more prevalent in areas with hot climates and poor sanitation. Outbreaks are more common during heavy rainfall and flooding, which leads to fecal contamination of the drinking water. Food-borne outbreaks also occur, especially with contaminated shellfish. HEV genotypes have their own geographic distribution. HEV-1 is common in high endemic areas of Asia and Africa. HEV-2 can be found in Mexico andWest Africa. HEV-3 has been found in rare cases in the USA and several developed countries in Europe, Japan, Australia, New Zealand, Korea, and Argentina. HEV-4 causes sporadic human cases in Southeast Asia and Japan. HEV-3 and HEV-4 are also reported in pigs on all continents, causing sporadic disease in humans. | hev is more prevalent in areas with hot climates and poor sanitation. outbreaks are more common during heavy rainfall and flooding, which leads to fecal contamination of the drinking water. hev genotypes have their own geographic distribution. |
CommunicabilityCommunicability - Original textNaN | - |
Prepatent periodPrepatent period - Original textNaN | - |